The Intracellular Growth of Fowl-Plague Virus

Abstract

Fowl-plague virus was inoculated into tissue cultures and the growth examined by means of the phase-contrast and electron microscope at intervals of from 6-72 hrs. No virus particles could be seen until after 36 hrs. when they appeared in the cytoplasm as bundles of filaments which seemed to come from the nucleus. No elementary bodies were seen until later. It would appear that the virus first invades the nucleus, where it multiplies, later extending in a filamentous form into the cytoplasm. Some of the filaments finally undergo segmentation into elementary bodies.