Studies in detoxication

Abstract

When sulphanilamide is fed to rabbits, the ethereal sulphate output in the urine is increased proportional to the dose of drug (0.2-1.0 g./Kg.) fed. Assuming that 1 molecule of the conjugated sulphate is formed from 1 molecule of sulphanilamide, then 6-12% of the dose of drug gives rise to a hydroxy body, probably a phenol, which is excreted combined with sulphate.