The effects of atropine and dyflos on tremor and increase in whole brain acetylcholine produced by injection of oxotremorine in the rat

Abstract

1 Injection of oxotremorine in the rat results in tremor and an increase in brain acetylcholine. The effects of atropine and dyflos have been investigated on both these actions. 2 Atropine decreased brain acetylcholine concentration and inhibited oxotremorine-tremor. It did this in doses which did not prevent the oxotremorine-induced increase in whole brain acetylcholine. 3 Dyflos increased brain acetylcholine concentration, but it was without effect on oxotremorine tremor. Some mutual antagonism was observed between the actions of oxotremorine and dyflos on rat brain acetylcholine concentration. 4 These results do not support a causal relationship between the increase in whole brain acetylcholine and the tremor produced by oxotremorine.