Chromium(VI) Oxide Catalyzed Oxidation of Sulfides to Sulfones with Periodic Acid
- 23 May 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 68 (13), 5388-5391
- https://doi.org/10.1021/jo030031n
Abstract
A highly efficient and selective oxidation of sulfides to sulfones with periodic acid catalyzed by CrO3 is described. A variety of electron-rich and electron-deficient sulfides were oxidized to sulfones with 2 mol % CrO3 in acetonitrile at room temperature in excellent yields. Sulfides with other readily oxidized functional groups were selectively oxidized to sulfones in high yields with 10 mol % CrO3 in ethyl acetate/acetonitrile at −35 °C.Keywords
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