Activation Product, Factor IX, Serum Thrombotic Accelerator Activity, and Serum-induced Thrombosis*
Open Access
- 1 February 1964
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 43 (2), 160-166
- https://doi.org/10.1172/jci104900
Abstract
The thrombogenicity of infusions of glass-contacted normal and Factor IX-deficient human serum in rabbits and the AP and Factor IX content of these infusates were determined. Glass-contacted Factor DC-deficient serum was markedly less thrombogenic than normal human serum. The thrombogenicity of glass contacted Factor IX -deficient serum did not correlate with its level of A P. Although elaboration of serum thrombotic accelerator (STA) activity is dependent on the contact activation steps involved in the formation of intrinsic thromboplastin, STA activity cannot be equated with the activity measured by the one-stage partial thromboplastin assay of AP. Thus, STA activity is not the in vivo manifestation of AP. Factor IX, or an associated moiety in serum, plays a critical role in the formation of stasis thrombi induced by infusions of human serum.Keywords
This publication has 16 references indexed in Scilit:
- Thrombosis in the presence of vascular stasisAmerican Journal Of Medicine, 1962
- Factor IX in Intravascular and Extravascular Blood CoagulationBlood, 1962
- THE THROMBOTIC ACTIVITY OF ACTIVATION PRODUCT*JCI Insight, 1962
- Studies on the In Vivo Behavior of Blood Coagulation Product I in RatsThrombosis and Haemostasis, 1962
- A One-stage Factor VIII (Antihaemophilic Globulin) Assay and its Use on Venous and Capillary PlasmaThrombosis and Haemostasis, 1962
- A Naturally Occurring Inhibitor of Christmas Factor (Factor IX)Thrombosis and Haemostasis, 1961
- The Prephase Accelerator. Present StatusThrombosis and Haemostasis, 1961
- THE ROLE OF HUMAN COAGULATION FACTORS IN SERUM-INDUCED THROMBOSIS *JCI Insight, 1960
- Biologic assay of a thrombosis-inducing activity in human serumJournal of Applied Physiology, 1959
- The Hereditary Haemorrhagic Diseases: Their Classification and DiagnosisBMJ, 1959