The effect of oestrone on the metabolism of rat uterus

Abstract

Anaerobic glycolysis of uteri from oophorectomized rats showed great variation in rate, ranging from the high values typical of pro-estrus to the low values found in late di-estrus in intact rats. Following inj. of estrone an increase in the rate of anaerobic glycolysis was observed after 6-12 hr., but the maximal rate was not reached until 24-36 hr. after inj., at the same time as maximal growth is known to occur. After 72 hr. the rate had fallen below, but after 96 hr. it had returned to the pre-inj. level; at this time the wt. is known to return to the original value. If injs. were continued for 5 days the glycolytic rate was not maintained at the maximal level. The effect of inj. on the O2 consumption was not so pronounced as on the rate of anaerobic glycolysis, but 36 hr. after inj. the rate of O2 consumption had increased. Hy-pophysectomy did not affect the action of estrone in raising the rate of anaerobic glycolysis. Neither estrone nor estriol had any in vitro action on the rate of anaerobic glycolysis of isolated uterus.