Two classes of translational control RNA: their role in the regulation of protein synthesis.
- 1 April 1975
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 72 (4), 1523-1527
- https://doi.org/10.1073/pnas.72.4.1523
Abstract
Two classes of translation control RNA (tcRNA) have been isolated from embryonic chick muscle. One of these classes, the tcRNA isolated from messenger ribonucleoprotein particles (mRNP-tcRNA), is effective in inhibiting the translation of mRNP-mRNA while having little if any effect on polysomal mRNA. The other class, polysome-tcRNA, has no effect on mRNP-mRNA while it stimulates the translation of polysomal mRNA. The mRNP tcRNA contains approximately 50 percent uridylate residues and forms small but stable hybrids with poly (A), while polysome-tcRNA contains fewer uridylate residues and is much less effective in forming a hybrid with poly (A). A proposed model concerning the role of these two classes of tcRNA in the regulation of protein synthesis is presented.Keywords
This publication has 12 references indexed in Scilit:
- Poly(A) in mRNA does not contribute to secondary structure necessary for protein synthesisCell, 1974
- Separation of Specific Initiation Factors Involved in the Translation of Myosin and Myoglobin Messenger RNAs and the Isolation of a New RNA Involved in TranslationProceedings of the National Academy of Sciences, 1974
- Eukaryotic Messenger RNAAnnual Review of Biochemistry, 1974
- Translation of mouse globin messenger ribonucleic acid from which the poly(adenylic acid) sequence has been removedBiochemistry, 1974
- Discrimination between Messenger Ribonucleic Acids by a Mammalian Translation Initiation FactorProceedings of the National Academy of Sciences, 1973
- Purification of a Messenger‐Specific Initiation Factor from Ascites‐Cell SupernatantEuropean Journal of Biochemistry, 1973
- Occurrence of Uridylate-Rich Oligonucleotide Regions in Heterogeneous Nuclear RNA of HeLa CellsProceedings of the National Academy of Sciences, 1972
- Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-CelluloseProceedings of the National Academy of Sciences, 1972
- The identification of polyribosomes synthesizing myosin.Proceedings of the National Academy of Sciences, 1967
- Ion-exchange thin-layer chromatographyAnalytical Biochemistry, 1965