A High Frequency of Cytotoxic Precursor Cells for a Syngeneic Tumour
- 1 October 1979
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 10 (4), 349-352
- https://doi.org/10.1111/j.1365-3083.1979.tb01362.x
Abstract
The average frequency of cytotoxic precursor cells in DBA/2 [mouse] lymph node cell preparations reactive to the syngeneic tumor P815 [mastocytoma] was determined as 1 in 2000. This frequency is similar to precursor frequency for an allogeneic tumor EL-4 [lymphoma]. The normal lack of response of DBA/2 lymph node cells to the syngeneic tumor P815 in vitro cannot be attributed to lack of cytotoxic precursor cells. In this tumor-host system non-immunogenicity reflects a defect at the inductive step.This publication has 8 references indexed in Scilit:
- GENERATION OF HOMOGENEOUS POPULATIONS OF ALLOREACTIVE T CELLS IN VITROImmunology & Cell Biology, 1979
- Cytotoxic T Cell Responses to a Syngeneic Tumour: Conditions for Primary Activation In Vitro and Biological Activity In VivoPublished by Springer Nature ,1979
- CYTOTOXIC T CELL RESPONSES TO A SYNGENEIC TUMOUR: CONDITIONS FOR PRIMARY ACTIVATION IN VITROImmunology & Cell Biology, 1978
- Activation of cytotoxic T cells by nonstimulating tumor cells and spleen cell factor(s).Proceedings of the National Academy of Sciences, 1977
- The Origin and Mechanism of the Allograft ReactionImmunological Reviews, 1977
- Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors.The Journal of Experimental Medicine, 1977
- Water-soluble P-815 mastocytoma membrane antigens: Separation of tumour-associated antigens from histocompatibility antigensImmunochemistry, 1976
- A NEW ANALYSIS OF ALLOGENEIC INTERACTIONSImmunology & Cell Biology, 1975