The effect of cholestyramine on intestinal absorption.
- 1 February 1975
- Vol. 16 (2), 93-98
- https://doi.org/10.1136/gut.16.2.93
Abstract
Cholestyramine in a mean dosage of 0-6 g/kg/day has been given to 18 children with familial hypercholesterolaemia for between one and two and a half years. With prolonged treatment folate deficiency occurred, as evidenced by a fall in the mean serum folate concentration from 7-7 ng/ml before treatment to 4-4 ng/ml for patients on treatment for over one year; a corresponding lowering of red cell folate was also seen. Oral folic acid 5 mg daily overcame this depletion, and should be given to all patients on long-term anion exchange resins. Prothrombin time has remained normal in all patients; there has been a significant decrease in the mean serum concentrations of vitamins A and E and of inorganic phosphorus over the first two years of treatment, although values remain within the normal range. The routine administration of fat-soluble vitamins appears unnecessary but it is prudent to measure prothrombin time and serum vitamins A and E at intervals. In children who were having a normal intake of dietary fat five out of seven tested had faecal fat of over 5 g/day while on cholestyramine. No chold has developed diarrhoea, and growth has been normal. The concentrations of serum iron, vitamin B12, plasma calcium, and protein did not change significantly in any patient.Keywords
This publication has 20 references indexed in Scilit:
- Serum Parathyroid Hormone and Blood Minerals: Interrelationships in Normal ChildrenPediatric Research, 1973
- Acquired Hyperoxaluria, Nephrolithiasis, and Intestinal DiseaseNew England Journal of Medicine, 1972
- Quantification of the Binding Tendencies of Cholestyramine II: Mechanism of Interaction with Bile Salt and Fatty Acid Salt AnionsJournal of Pharmaceutical Sciences, 1970
- Hypoprothrombinemia and Hemorrhage Associated with Cholestyramine TherapyAnnals of Internal Medicine, 1970
- Effect of cholestyramine on the absorption of vitamin D3 and calciumGut, 1969
- Cholestyramine Treatment of Diarrhea Associated with Ileal ResectionNew England Journal of Medicine, 1969
- Treatment of Pruritus of Obstructive Jaundice with CholestyramineBMJ, 1963
- XANTHOMATOUS BILIARY CIRRHOSIS TREATED WITH CHOLESTYRAMINE: A Bile-acid-adsorbing ResinThe Lancet, 1961
- Experimental Steatorrhea Induced in Man by Bile Acid Sequestrant.Experimental Biology and Medicine, 1961
- Effect of an Anion Exchange Resin on Serum Cholesterol in Man.Experimental Biology and Medicine, 1959