Bromocriptine holiday
- 1 March 1986
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 36 (3), 400
- https://doi.org/10.1212/wnl.36.3.400
Abstract
In experimental Parkinson's disease, we studied the effects of chronic administration (30 days), withdrawal, and reinstitution of bromocriptine. Dopamine (DA) receptor supersensitivity was produced by 6-hydroxydopamine and reversed by chronic bromocriptine administration. Drug holiday reestablished sensitivity of DA receptors, but reinstitution of bromocriptine again downregulated receptors. The effects of a drug holiday on DA receptors are shortlived, and long-term clinical improvement cannot be expected. Apomorphine-induced contralateral turning produced by the lesion was unaffected by any drug regimen.This publication has 6 references indexed in Scilit:
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