The long 3′‐untranslated regions of the PDGF‐A and ‐B mRNAs are only distantly related
- 2 November 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 223 (2), 243-246
- https://doi.org/10.1016/0014-5793(87)80297-1
Abstract
A cDNA clone of about 2300 base pairs was prepared from the human osteosarcoma cell line U‐2 OS by hybridization with a 22‐mer oligonucleotide complementary to the NH2‐terminus of PDGF‐A. Restriction and sequence analysis showed that this clone contains the entire coding region for PDGF‐A and a long 3′‐untranslated region which is only distantly related to that in the mRNA of PDGF‐B.Keywords
This publication has 19 references indexed in Scilit:
- Platelet‐derived growth factor Phorbol ester induces the expression of the B‐chain but not of the A‐chain in HEL cellsFEBS Letters, 1987
- cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell linesNature, 1986
- The human osteosarcoma cell line U‐2 OS expresses a 3.8 kilobase mRNA which codes for the sequence of the PDGF‐B chainFEBS Letters, 1986
- A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chainsNature, 1986
- Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequencesCell, 1985
- Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: Implications for autocrine receptor activationCell, 1984
- Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth FactorScience, 1983
- Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virusNature, 1983
- TECHNOLOGICAL EXAMINATION OF LOW‐FIRED TERRACOTTA STATUES FROM AYIA IRINI, KEAArchaeometry, 1982
- Platelet-derived growth factor: Identification of constituent polypeptide chainsBiochemical and Biophysical Research Communications, 1982