Quantitative and functional aspects of T-cell populations in human gut mucosa
- 1 July 1979
- journal article
- Published by Springer Nature in La Ricerca in Clinica e in Laboratorio
- Vol. 9 (3), 237-244
- https://doi.org/10.1007/bf02932175
Abstract
Lymphocytes were isolated from rectal biopsies and resected gut specimens through a simple mechanical technique, and assayed for T-cell quantitation and mitogenic response to PHA and PPD. T-cells were found in considerable numbers in gut mucosa of all groups, but in each case their percentage was lower than that of the autologous peripheral blood. The mitogenic response to PHA was found in general to be lower in the mucosal lymphocytes compared to those in blood, with the exception of the polyposis group which responded highly. No response of mucosal cells to PPD was seen. Inhibition studies done by means of mixed cultures revealed the presence of a suppressor activity in many mucosal lymphocytes, especially in the inflamed mucosa group, which may partly account for some low responses observed with mucosal lymphocytes. Further studies are under way to better define these quantitative and functional differences seen in gut mucosal cells, and to correlate differences with disease states.Keywords
This publication has 3 references indexed in Scilit:
- Absence of K cells in human gut mucosa.Gut, 1978
- Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG.The Journal of Experimental Medicine, 1977
- SURFACE MARKERS ON HUMAN T AND B LYMPHOCYTESThe Journal of Experimental Medicine, 1972