Optimization of preservatives in a topical formulation using experimental design
- 1 December 2009
- journal article
- Published by Wiley in International Journal of Cosmetic Science
- Vol. 31 (6), 451-460
- https://doi.org/10.1111/j.1468-2494.2009.00520.x
Abstract
Optimizing the preservative regime for a preparation requires the antimicrobial effectiveness of several preservative combinations to be determined. In this study, three preservatives were tested: benzoic acid, sorbic acid and benzylic alcohol. Their preservative effects were evaluated using the antimicrobial preservative efficacy test (challenge-test) of the European Pharmacopeia (EP). A D-optimal mixture design was used to provide a maximum of information from a limited number of experiments. The results of this study were analysed with the help of the Design Expert software and enabled us to formulate emulsions satisfying both requirements A and B of the EP.Keywords
This publication has 11 references indexed in Scilit:
- Optimization of poorly compactable drug tablets manufactured by direct compression using the mixture experimental designInternational Journal of Pharmaceutics, 2006
- Construction of predictive models of growth of microorganisms in salted and cured meat productsInnovative Food Science & Emerging Technologies, 2006
- Determination of optimal cream formulation from long‐term stability investigation using a surface response modellingInternational Journal of Cosmetic Science, 2006
- Method for evaluation of the efficacy of antimicrobial preservatives in cosmetic wet wipesInternational Journal of Cosmetic Science, 2005
- Basis of predictive mycologyInternational Journal of Food Microbiology, 2005
- The mathematical properties of the quasi-chemical model for microorganism growth–death kinetics in foodsInternational Journal of Food Microbiology, 2005
- Optimal dynamic experiment design for estimation of microbial growth kinetics at sub-optimal temperatures: Modes of implementationSimulation Modelling Practice and Theory, 2005
- Development of a multidose formulation for a humanized monoclonal antibody using experimental design techniquesAAPS PharmSci, 2003
- Challenge testing: principles and practiceInternational Journal of Cosmetic Science, 2003
- Development and optimization of pharmaceutical formulations using a simplex lattice designInternational Journal of Clinical Pharmacy, 1984