Effect of Oral 688A (N-Phenoxyisopropyl-N-Benzyl- -Chloroethylamine Hydrochloride) on Blood Pressure in Normotensive and Hypertensive Subjects.

Abstract

688A (N-phenoxyisopropyl-N-benzyl-beta-chloroethylamine hydrochloride), a new adrenergic blocking agent was studied in 47 subjects (19 normotensives and 28 hypertensives). Given orally it induces a fall in both supine and erect blood pressures in all subjects. The duration of the decrease in B.P. following a single dose is variable and usually lasts 3-5 hrs. Symptomatic improvement occurred in 16 of 22 patients with hypertension. Cold pressor tests showed that 688A usually induced partial inhibition. Side effects of this drug were few and minor. Tolerance to the drug was noted in a few cases. While individual responses to the drug were variable, the overall results in the entire group of patients indicate that 688A is effective orally in lowering B.P. and alleviating hypertensive symptoms.