URINE EXCRETION DURING ANOXIA FROM NORMAL AND DENERVATED KIDNEYS IN DOGS WITH AND WITHOUT ADRENAL GLANDS

Abstract

The elimination of the adrenal secretion from the circulatory system in 14 expts. performed on 12 anesthetized (Dial) dogs did not prevent the oliguria that usually occurs during the anoxia resulting from the inhalation, through the cannulated trachea, of low O-high N gas mixtures. The 0 conc. varied from 6 to 12%. Urine rates of each kidney were recorded continuously from cannulated ureters. The adrenal secretion was prevented from getting into the circulation by occluding the veins approaching and leaving the glands. 17 additional expts were performed on 17 anesthetized dogs in which one kidney was acutely denervated. The urinary response of the normal kidney to anoxia was the oliguria that occurred in the first series of expts., the oliguria being independent of changes in the carotid blood pressure. In contrast to this the response of the denervated kidney to the anoxia varied directly with changes in the carotid blood pressure. The elimination of the adrenal glands again did not alter the responses of the normal and denervated kidneys during the anoxia. Apparently the renal nerve supply is the primary factor affecting the urinary responses during the anoxia.