Factors that inhibit adherence of Treponema pallidum (Nichols strain) to a human fibroblastic cell line: development in serum of patients with syphilis.
Open Access
- 1 April 1987
- journal article
- Published by BMJ in Sexually Transmitted Infections
- Vol. 63 (2), 71-76
- https://doi.org/10.1136/sti.63.2.71
Abstract
Serum samples from 25 patients at five different stages of syphilis were investigated for their ability to inhibit the adherence of pathogenic Nichols treponemes to cultured human fibroblasts. Serum taken from patients at the end of the primary stage showed an appreciable inhibition of treponemal adherence, and maximum inhibition of adherence was produced by serum from patients with secondary syphilis. Some freshly harvested treponemal suspensions were resistant to the adherence inhibition factors in serum from patients with syphilis; after incubation in vitro for 24 hours this resistance was lost. In vitro incubation almost doubled the number of adherent treponemes/fibroblast. These phenomena are discussed in terms of loss and reconstruction of the treponemal outer envelope. This leads to the suggestion that adherence occurs not only at the tips of the treponemes, but that surface components are also implicated, possibly as an initial contact mechanism. The composition of the outer envelope may in this way determine localisation versus dissemination of the treponemes.Keywords
This publication has 10 references indexed in Scilit:
- Transfusion Syphilis, Survival of Treponema pallidum in Stored Donorblood1Vox Sanguinis, 1985
- Interactions of fibronectin with Treponema pallidum.Sexually Transmitted Infections, 1985
- Transfusion syphilis, survival of Treponema pallidum in stored donor blood. II. Dose dependence of experimentally determined survival times.1985
- Effect of syphilitic rabbit sera taken at different periods after infection on treponemal motility, treponemal attachment to mammalian cells in vitro, and treponemal infection in rabbits.Sexually Transmitted Infections, 1983
- Treponema pallidum receptor binding proteins interact with fibronectin.The Journal of Experimental Medicine, 1983
- Molecular characterization of receptor binding proteins and immunogens of virulent Treponema pallidum.The Journal of Experimental Medicine, 1980
- Epidermal antibodies in secondary syphilis.Sexually Transmitted Infections, 1978
- Demonstration of extracellular material at the surface of pathogenic T. pallidum cells.Sexually Transmitted Infections, 1976
- IMMUNOGLOBULINS IN SYPHILISThe Lancet, 1969
- STUDY OF THE ANTIGENIC STRUCTURE OF TREPONEMA PALLIDUM BY SPECIFIC AGGLUTINATION2American Journal of Epidemiology, 1957