Steric Rejection of Polymeric Solutes by Membranes with Uniform Pore Size Distribution

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Abstract
The analysis of steric rejection by membranes with uniform pore size distribution is described. The uncharged polymeric solutes (polyethylene oxides, dextrans) are modeled as hard spheres, and the rejection in capillaries is corrected for hydrodynamic lag. The experimental data obtained with Carbowax and Dextran T solutes and track-etched Nuclepore membranes support the general validity of this model. Both single solute rejection data as well as GPC-monitored rejection data obtained with blend solutions are in good agreement with the theory.