Phospholipase C-induced neural tube defects in the mouse embryo
- 1 October 1980
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 36 (10), 1217-1219
- https://doi.org/10.1007/bf01976138
Abstract
Mouse embryo neurulae were exposed in vitro to phospholipase C to examine the role of carbohydrate-rich extracellular material (ECM) during neurulation. Exposure of embryos to this agent for 12 h resulted in failure of closure of the neural tube. Ultrastructural examination revealed an absence of ECM from regions of the neural tube which failed to close.This publication has 18 references indexed in Scilit:
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