Restriction in the immune response to flagellar proteins in inbred mice

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Abstract
Anti‐idiotypic sera prepared in both AL/N mice and rabbits identify specificities common t o the IgA MOPC 467 myeloma protein and day‐7 affinityabsorbed antibodies t o Salmonella milwaukee polymerized flagellin (S.mi1 POL) raised in BALB/c and C57BL/Ka mice. Isoelectric focusing (IEF) of reduced and alkylated BALB/c anti‐S.mil‐POL gave a banding pattern of L and H‐chains identical to MOPC 467. C57BL/Ka anti‐S.mi1‐POL had a similar Lchain pattern but a different H‐chain pattern. Both BALB/c and C57BL/Ka contain predominantly IgA. The IEF patterns in the two strains are consistent with a monoclonal response at day 7.