An Inhibitory Effect of Melatonin on the Estrous Phase of the Estrous Cycle of the Rodent
- 1 August 1964
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 75 (2), 238-242
- https://doi.org/10.1210/endo-75-2-238
Abstract
Microgram doses of melatonin decrease the incidence of vaginal smears that demonstrate estrous phases in Sprague- Dawley rats and C3H/HeN mice. This property is not shared by the precursors of melatonin, serotonin and N-acetylserotonin, or its major metabolite, 6-hydroxymelatonin. The minimum effective dose of melatonin is decreased when daily melatonin injections are started prior to gonadal maturation. Pinealectomy is followed by an increase in the incidence of estrus; this increase is inhibited by melatonin treatment. (Endocrinology75: 238, 1964)Keywords
This publication has 8 references indexed in Scilit:
- Melatonin Synthesis in the Pineal Gland: Effect of Light Mediated by the Sympathetic Nervous SystemScience, 1964
- Melatonin Synthesis in the Pineal Gland: Control by LightScience, 1963
- Melatonin, a Pineal Substance: Effect on the Rat OvaryScience, 1963
- The Fate of Melatonin in AnimalsJournal of Biological Chemistry, 1961
- INTERACTIONS OF THE PINEAL AND EXPOSURE TO CONTINUOUS LIGHT ON ORGAN WEIGHTS OF FEMALE RATSActa Endocrinologica, 1961
- The pineal gland and aldosteroneAmerican Journal of Physiology-Legacy Content, 1960
- Isolation of Melatonin and 5-Methoxyindole-3-acetic Acid from Bovine Pineal GlandsJournal of Biological Chemistry, 1960
- Enzymatic O-Methylation of N-Acetylserotonin to MelatoninScience, 1960