Associations of Pentraxin 3 With Cardiovascular Disease and All-Cause Death
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- 1 April 2009
- journal article
- research article
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 29 (4), 594-599
- https://doi.org/10.1161/atvbaha.108.178947
Abstract
Objective— We examined associations of pentraxin 3 (PTX3), a vascular inflammation marker, with incident cardiovascular disease (CVD) and all-cause death. Methods and Results— 1583 Cardiovascular Health Study participants free of prevalent CVD were included. Nonexclusive case groups were angina (n=476), myocardial infarction (MI; n=237), stroke (n=310), CVD death (n=282), and all-cause death (n=772). 535 participants had no events. PTX3 levels were higher in those with subclinical CVD (1.90±1.89 ng/mL) than those without (1.71±1.88 ng/mL; P =0.001). Using Cox regression adjusted for age, sex, and ethnicity, a standard deviation increase in PTX3 (1.89 ng/mL) was associated with CVD death (hazard ratio 1.11; 95% confidence interval 1.02 to 1.21) and all-cause death (1.08; 1.02 to 1.15). PTX3 was not associated with angina (1.09; 0.98 to 1.20), MI (0.96; 0.81 to 1.12), or stroke (1.06; 0.95 to 1.18). Adding C-reactive protein (CRP) or CVD risk factors to the models had no significant effects on associations. Conclusions— In these older adults, PTX3 was associated with CVD and all-cause death independent of CRP and CVD risk factors. PTX3 likely reflects different aspects of inflammation than CRP and may provide insight into vascular health in aging and chronic diseases of aging that lead to death.Keywords
This publication has 28 references indexed in Scilit:
- Plasma Pentraxin 3 in Patients with Chronic Kidney DiseaseClinical Journal of the American Society of Nephrology, 2007
- Serum Amyloid P and Cardiovascular Disease in Older Men and WomenArteriosclerosis, Thrombosis, and Vascular Biology, 2007
- Establishment of a High Sensitivity Plasma Assay for Human Pentraxin3 as a Marker for Unstable Angina PectorisArteriosclerosis, Thrombosis, and Vascular Biology, 2007
- Membrane and soluble pattern recognition receptors: the unique functions of the long pentraxin PTX3Clinical & Experimental Allergy Reviews, 2004
- The long pentraxin PTX3 up-regulates tissue factor in activated monocytes: another link between inflammation and clotting activationJournal of Leukocyte Biology, 2004
- C-Reactive Protein, Carotid Intima-Media Thickness, and Incidence of Ischemic Stroke in the ElderlyCirculation, 2003
- Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune responseNature, 2002
- Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?Atherosclerosis, 2000
- The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A proteinImmunology Today, 1994
- The cardiovascular health study: Design and rationaleAnnals of Epidemiology, 1991