Cultivation and Modification of Infectious Canine Hepatitis Virus in Roller Tube Cultures of Dog Kidney
- 1 August 1954
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 86 (4), 819-823
- https://doi.org/10.3181/00379727-86-21242
Abstract
The virus of infectious canine hepatitis was propagated through 70 successive passages in roller tube tissue cultures of dog kidney accompanied by production of distinct cytologic changes. After 51 serial passages, the virus apparently had lost its former virulence for dogs, although still capable of producing a solid immunity. A neutralization test in tissue culture was developed and used as a sen-sitive diagnostic aid. Virus was isolated directly from the blood or liver of infected dogs.Keywords
This publication has 5 references indexed in Scilit:
- Propagation of Infectious Canine Hepatitis Virus in Tissue CultureExperimental Biology and Medicine, 1954
- PLAQUE FORMATION AND ISOLATION OF PURE LINES WITH POLIOMYELITIS VIRUSESThe Journal of Experimental Medicine, 1954
- Persistence of Virus in Urine as Factor in Spread of Infectious Hepatitis in Dogs.Experimental Biology and Medicine, 1951
- Cytopathogenic Effect of Poliomyelitis Viruses In vitro on Human Embryonic Tissues.Experimental Biology and Medicine, 1950
- Cultivation of Poliomyelitis Virus in Cultures of Human Foreskin and Embryonic Tissues.Experimental Biology and Medicine, 1949