Interaction of Nutrition and Infections Globally: An Overview
Open Access
- 1 January 2012
- journal article
- Published by S. Karger AG in Annals of Nutrition and Metabolism
- Vol. 61 (Suppl. 1), 39-45
- https://doi.org/10.1159/000345162
Abstract
The interaction of nutrition and infections is known by experience by generations of medical doctors. Before the era of antibiotics, diet was an integral part of the management of infections. Now, it is necessary to take a fresh look at this interaction as the understanding of immune response has expanded considerably. Comparatively little research has addressed the impact of nutrition interventions on the management of infectious diseases. Most observations of the interaction between nutrition and infections are epidemiological in character. This holds especially true for measles as well as for tuberculosis. In AIDS, the deterioration of the nutritional status is an indicator of disease progression. Infections in undernourished children are a common cause of death, and taking this finding into account helps to reduce the case fatality rate in severely malnourished patients. Regarding the immune response, cellular as well as soluble components are affected by deficiencies of single nutrients or general undernutrition. The immunosuppressive effect of undernutrition starts during intrauterine life already: maternal nutrition status has been shown to impact on immune function in adult animals. Recent research suggests that not only undernutrition but also caloric overnutrition impacts on immune response to infections and immunization. This is partly due to the chronic inflammatory activity of the adipose tissue and partly due to neuroendocrine alterations. Infectious diseases also impact on the nutritional status, either specifically or through unspecific mechanisms, such as anorexia, tachypnea, and vomiting.Keywords
This publication has 36 references indexed in Scilit:
- Research Questions and Priorities for Tuberculosis: A Survey of Published Systematic Reviews and Meta-AnalysesPLOS ONE, 2012
- Is the BCG Vaccine Safe for Undernourished Individuals?Clinical and Developmental Immunology, 2012
- Epidemiology of Malaria, Schistosomiasis, Geohelminths, Anemia and Malnutrition in the Context of a Demographic Surveillance System in Northern AngolaPLOS ONE, 2012
- Household and community HIV/AIDS status and child malnutrition in sub-Saharan Africa: Evidence from the demographic and health surveysSocial Science & Medicine, 2011
- Cord Blood Vitamin D Status Impacts Innate Immune ResponsesJournal of Clinical Endocrinology & Metabolism, 2011
- Recent Food Shortage Is Associated with Leprosy Disease in Bangladesh: A Case-Control StudyPLoS Neglected Tropical Diseases, 2011
- Malnutrition and Helminth Infection Affect Performance of an Interferon γ–Release AssayPediatrics, 2010
- Inhibition of Human Immunodeficiency Virus Type 1 by Lactic Acid Bacteria from Human BreastmilkBreastfeeding Medicine, 2010
- Alterations in early cytokine-mediated immune responses to Plasmodium falciparum infection in Tanzanian children with mineral element deficiencies: a cross-sectional surveyMalaria Journal, 2010
- Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health spanJournal of Leukocyte Biology, 2008