Nanoscale Atmospheric Pressure Laser Ablation-Mass Spectrometry
- 23 February 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 73 (7), 1399-1402
- https://doi.org/10.1021/ac001440b
Abstract
We describe an atmospheric pressure nanosampling interface for mass spectrometry based on near-field laser ablation. Pulsed laser radiation is delivered to the sample surface through a near-field optical probe, and the ablation plume is sampled through a capillary orifice and analyzed by standard MS methods. A spatial resolution of less than 200 nm and a sensitivity below 2 amol is demonstrated.Keywords
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