Widespread neural excitation initiated from cardiac spinal afferent nerves

Abstract

Reflex effects of cardiac sympathetic afferent nerve excitation on cardiac and renal components of sympathetic outflow were well investigated, but the extent of these cardiac afferent influences on other sympathetic nerves or on respiratory or cortical neural systems is unknown. These influences were investigated electrophysiologically in anesthetized, vagotomized, baroreceptor-denervated cats. Stimulation of cardiac sympathetic spinal afferent neurons by the noxious substrate bradykinin caused excitation of cardiac, renal, splenic, gastrohepatic, adrenal and deep peroneal (muscle) vasoconstrictor sympathetic nerves, as well as excitation of phrenic nerves and concomitant desynchronization of the EEG. Possible supraspinal pathways mediating these responses were investigated. Sympathetic reflexes caused by cardiac afferent stimulation were unchanged after decerebration, thereby demonstrating that supramedullary mediation was not essential to the sympathetic responses. Potential contributions of the medulla to the observed sympathetic or other responses were demonstrated by recording from medullary neurons responsive to electrical and chemical stimulation of the afferent nerves. Noxious stimulation of cardiac sympathetic afferent neurons leads to widespread neural excitation which may contribute to sensory, visceral and somatic responses caused by cardiac pain or which occur during activated states such as exercise or emotional stress.