Peptic ulcer and non-steroidal anti-inflammatory agents.
Open Access
- 1 August 1986
- Vol. 27 (8), 929-933
- https://doi.org/10.1136/gut.27.8.929
Abstract
Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. To investigate this we conducted a case control study of 180 matched pairs of peptic ulcer patients and controls obtained from surgical and dermatology outpatient clinics. There were 95 gastric ulcer and 85 duodenal ulcer patients. A statistically and clinically association (relative risk = 5) was found between the regular use of non-steroidal anti-inflammatory agents and gastric ulcer. There was also evidence of positive associations between gastric ulcer and aspirin containing preparations with or without non-steroidal anti-inflammatory agents. By contrast, duodenal ulcer was unrelated to these drugs. Too few patients used paracetamol for any conclusion to be drawn on its role.This publication has 16 references indexed in Scilit:
- Environmental factors in aetiology of chronic gastric ulcer: a case control study of exposure variables before the first symptoms.Gut, 1985
- What is happening to peptic ulcer?BMJ, 1982
- Analgesic ingestion and chronic peptic ulcerGastroenterology, 1981
- Gastroscopic evaluation of anti-inflammatory agentsBMJ, 1980
- A review of upper-gastrointestinal effects of the newer nonsteroidal antiinflammatory agentsDigestive Diseases and Sciences, 1979
- Effect of paracetamol on gastric mucosa.BMJ, 1978
- Progress report. Aspirin in chronic gastric ulcer: an Australian experience.Gut, 1976
- Aspirin and gastric ulcer.1975
- Aspirin ingestion and perforated peptic ulcerGut, 1972
- Aspirin and uncomplicated peptic ulcer.Gut, 1969