Anti-inflammatory activity of oleanolic acid in rats and mice

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Abstract
— Oleanolic acid displayed anti‐inflammatory activity in carrageenan and dextran‐induced oedema in rats. It elicited marked anti‐arthritic action in adjuvant‐induced polyarthritis in rats and mice and in formaldehyde‐induced arthritis in rats. Oleanolic acid checked the inflammation‐induced increased serum transaminase levels. It reduced exudate volume and inhibited leucocyte infiltration in carrageenan‐induced pleurisy in rats. It is devoid of any analgesic, antipyretic or ulcerogenic action. Oleanolic acid did not affect the parturition time in pregnant rats or castor oil‐induced diarrhoea in rats. Oral LD50 was found to be greater than 2 g kg−1 in mice and rats.