RELAXATION OF THE PELVIC LIGAMENTS IN GUINEA-PIGS BY ESTROGENS AND PROSTIGMINE

Abstract

Forty-eight normal and oophorectomized guinea-plgs were used in studies on exptl. relaxation of the pelvic ligaments. Relaxation of the pelvic ligaments was induced by long-continued action of either theelin or stilbestrol. Theelin and stilbestrol conditioned the pelvic ligaments within a few days in such a way that relaxation was readily induced by prostigmine. This conditioning effect lasted for as long as 3 or 4 wks. after the last injn. of estrogen. Prostigmine given alone to oophorectomized young virgin guinea-plgs did not induce relaxation of the pelvis. The ovaries do not seem to protect the pelvis from the action of prostigmine if the pelvic ligaments have been conditioned by the action of estrogens. Pelvic relaxation was obtained after hysterectomy.