New anthracycline glycosides from Micromonospora. I. Description of the producing strain.

Abstract

During the course of successive mutagenic treatments of Streptomyces peucetius var. caesius, producer of anthracyclines, a novel mutant was isolated from a plate of the surviving population. This mutant showed remarkable morphological, cultural and biochemical differences when compared to the original strain. The new culture produced 4 new glycosides of a novel class within the group of the daunorubicin related anthracyclines, 2 of which were also present in the original strain. This mutant was assigned to the genus Micromonospora. The possibilities of whether this new strain originated from a contamination or from a mutation are discussed. The type strain is Micromonospora sp. strain B 211 F.I. (= ATCC 31366; DSM 1190; FRI 4363).