New anthracycline glycosides from Micromonospora. II. Isolation, characterization and biological properties.
- 1 January 1980
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 33 (12), 1468-1473
- https://doi.org/10.7164/antibiotics.33.1468
Abstract
Four glycosides, designated A, B, C and D, are the main components of the anthracycline complex produced by cultures of Micromonospora sp. nov. They were extracted by solvent partition, separated by column chromatography and characterized by chemical and physical methods as 11-deoxy analogues of daunorubicin. Among these new anthracyclines, displaying antibacterial and cytotoxic activity in vitro, 11-deoxydaunorubicin and 11-deoxydoxorubicin are also active against P388 leukemia in mice.This publication has 2 references indexed in Scilit:
- New anthracycline glycosides from Micromonospora. I. Description of the producing strain.The Journal of Antibiotics, 1980
- Preparation and biological evaluation of 4-O-demethyldaunorubicin (carminomycin I) and of its 13-dihydro derivative.The Journal of Antibiotics, 1978