Quantitative metabolic profiling based on gas chromatography.
- 1 October 1978
- journal article
- review article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 24 (10), 1663-1673
- https://doi.org/10.1093/clinchem/24.10.1663
Abstract
The quantitative metabolic profiles of volatilizable components of human biological fluids, particularly urinary organic acids, is reviewed, with emphasis on the use of gas-chromatography/mass spectrometer/computer systems. Various definitions of metabolic profiling are considered and techniques for obtaining such profiles are discussed. The role of computer processing of such data is examined, and statistical techniques for treating quantitative metabolic profiles are suggested.This publication has 23 references indexed in Scilit:
- Urinary organic acids in man. I. Normal patterns.Clinical Chemistry, 1976
- Extraction of mass spectra free of background and neighboring component contributions from gas chromatography/mass spectrometry dataAnalytical Chemistry, 1976
- Assessment of interference by aspirin with some assays commonly done in the clinical laboratory.Clinical Chemistry, 1976
- Gas-liquid chromatographic profile of neutral and acidic metabolites in cerebrospinal fluid from newborns and infants.Clinical Chemistry, 1976
- Seasonal variation of urinary excretion of total metanephrinesClinica Chimica Acta; International Journal of Clinical Chemistry, 1976
- The unsuitability of creatinine excretion as a basis for assessing the excretion of other metabolites by infants and childrenClinica Chimica Acta; International Journal of Clinical Chemistry, 1975
- Identification and quantification of neutral fecal steroids by gas–liquid chromatography and mass spectrometry: studies of human excretion during two dietary regimensJournal of Lipid Research, 1964
- Two-dimensional paper chromatography of urinary indoles and related substancesBiochemical Journal, 1956
- PHENOLIC ACIDS OF HUMAN URINE - PAPER CHROMATOGRAPHY OF PHENOLIC ACIDS1956
- A new form of chromatogram employing two liquid phasesBiochemical Journal, 1941