HEMOLYTIC REACTIONS PRODUCED IN DOGS BY TRANSFUSION OF INCOMPATIBLE DOG BLOOD AND PLASMA

Abstract

The normal dog''s kidney reacts to the transfusion of incompatible dog blood in a manner similar to that observed after hemoglobin injn. as far as the excretion of the pigment is concerned. Lowering the pH of the urine to a level of 5.5 has no effect on the final outcome of the reaction nor on the mild, transient alterations in renal function which occur. This type of hemolytic transfusion reaction, similar in most respects to that encountered in human subjects, does not of itself produce renal failure nor the pathological picture of hemoglobinuric or lower nephron nephrosis.