Prostaglandin synthetase activity in kidney medulla during the development of experimental hypertension in the rat
- 1 October 1976
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 295 (1), 77-79
- https://doi.org/10.1007/bf00509776
Abstract
The activity of the Pg-E2-synthetase in the rat renal medulla was observed for a period of 27 days during the development of a hypertension by clamping of the renal artery; an increased activity of Pg-E2-synthetase with a peak on the 18th day was observed in the kidneys of the 2-kidney model (2-KM=stenosing of the left arteria renalis) and the 1-kidney model (1-KM=stenosing of the left arteria renalis and additional nephrectomy of the right kidney). The initial values of the enzyme activities were reached again on the 21st (1-KM) resp. 24th (2-KM) day post operationem.Keywords
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