Nucleotide Sequence of a Human Immunoglobulin Cγ4 Gene
- 1 January 1981
- journal article
- research article
- Published by Mary Ann Liebert Inc in DNA
- Vol. 1 (1), 11-18
- https://doi.org/10.1089/dna.1.1981.1.11
Abstract
We report the nucleotide sequence of a gene encoding the constant region of a human immunoglobulin γ4 heavy chain (Cγ4). These data represent the first complete sequence determination of a human CH gene. As expected from structural studies of mouse Cγ genes, the coding sequences for the CH domains and hinge segment are separated from one another by intervening DNA sequences. Comparison with genomic sequences of the mouse Cγ1, Cγ2a, and Cγ2b genes shows conservation of the sequences in the constant region domains and the 3′ untranslated region surrounding the presumed site of poly(A) addition.Keywords
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