STUDIES ON MENINGOCOCCAL INFECTION

Abstract

From meningococcus Type II broth autolysates, a substance, corresponding to the protective antibody has been isolated. This substance, termed kappa substance, is firmly connected with protein but can be separated by the action of proteolytic enzymes. Methods of preparation and purification are given, together with chemical and serological data. In whole cells from young cultures, this substance is also connected with protein, especially with one protein fraction which requires highest alkali concentration to effect solution.