Common variants of LRRK2 are not associated with sporadic Parkinson's disease

Abstract

Multiple mutations in the gene for the leucine‐rich repeat kinase (LRRK2) cause autosomal dominant late‐onset parkinsonism (PARK8). The Gly2019Ser mutation appears to be common in different populations. To investigate whether this novel gene influences the non‐Mendelian sporadic form of Parkinson's disease, we genotyped 121 single nucleotide polymorphisms comprehensively covering the entire LRRK2 gene region in a set of 340 Parkinson's disease patients and 680 matched control subjects from Germany. No association could be demonstrated. We have therefore no evidence for the existence of a common variant in LRRK2 that has a strong influence on Parkinson's disease risk. Ann Neurol 2005