Serum levels of antibodies againstActinobacillus actinomycetemcomitansin various forms of human periodontitis
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Acta Odontologica Scandinavica
- Vol. 47 (5), 271-277
- https://doi.org/10.3109/00016358909007712
Abstract
Serum levels of IgG, IgA, and IgM antibodies against extracts from Bacteroides gingivalis PER8, Actinobacillus actinomycetemcomitans Y4, and Bacteroides fragilis NCTC 9343 were determined in three categories of periodontitis patients by means of enzyme-linked immunosorbent assay. The test groups comprised 10 patients with juvenile periodontitis (JP), 18 young patients with severe periodontitis (YP), and 31 patients with adult periodontitis (AP). Nine subjects with healthy periodontium (HP) served as a reference group. Increased frequencies of patients with significantly elevated IgG and IgA antibody values against B. gingivalis and A. actinomycetemcomitans were found in the three periodontitis groups as compared with the HP group. The AP group, however, showed lower IgM values than the other groups. The results support the contention that A. actinomycetemcomitans may play a contributory role in adult periodontitis and that B. gingivalis is a suspected periopathogenic bacterium in juvenile periodontitis. The clinical YP classification was not supported by the present serologic findings.Keywords
This publication has 32 references indexed in Scilit:
- Immunologic dysfunction in the pathogenesis of periodontal diseases*Journal of Clinical Periodontology, 1987
- Microbiology of periodontal diseaseJournal of Periodontal Research, 1987
- Bacterial flora of progressing periodontitis lesionsJournal of Periodontal Research, 1987
- Serum antibodies in young adult humans reactive with periodontitis associated treponemesJournal of Periodontal Research, 1985
- IgG, IgA and IgM serum antibodies against lipopolysaccharide from Bacteroides gingivalis in periodontal health and diseaseJournal of Periodontal Research, 1985
- Activity of serum immunoglobulins G, A, and M to six anaerobic, oral bacteria in diagnosis of periodontitisJournal of Periodontal Research, 1985
- Immunological studies of young adults with severe periodontitisJournal of Periodontal Research, 1981
- Comparative antibody titers to Actinobacillus actinomycetemcomitans in juvenile periodontitis, chronic periodontitis and periodontally healthy subjectsJournal of Clinical Periodontology, 1981
- Polyclonal B-cell activation: Severe periodontal disease in young adultsClinical Immunology and Immunopathology, 1980
- Criteria for the infectious agents in dental caries and periodontal diseaseJournal of Clinical Periodontology, 1979