Restitution of blood volume after hemorrhage: role of the adrenal cortex
- 1 June 1976
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 230 (6), 1683-1687
- https://doi.org/10.1152/ajplegacy.1976.230.6.1683
Abstract
Splenectomized and adrenalectomized-splenectomized dogs, anesthetized with pentobarbital, were bled so that the role of cortisol in restitution of blood volume could be examined. Intact dogs and adrenalectomized dogs infused with cortisol at a high rate (17 mug/min) showed restoration of blood volume and plasma protein at 24 h, preceded by an early increase in plasma osmolality. Adrenalectomized dogs infused with cortisol at basal rates (2 mug/min) showed no increase in plasma osmolality and no restoration of blood volume or plasma protein at 24 h unless extracellular fluid volume was expanded by exogenous fluid. It is concluded that hemorrhage leads to an increase in extracellular osmolality mediated in part by increased cortisol concentrations. As a consequence, there is a shift of intracellular fluid to the interstitium. The resulting increase in interstitial pressure accelerates lymphatic movement of interstitial protein to the vascular system. This results in a reequilibration of extracellular fluid toward the plasma, thus completing the restitution of blood volume. The osmotically active agents mobilized by cortisol do not appear to be glucose, sodium, or potassium.This publication has 13 references indexed in Scilit:
- Responses of Adrenal Corticosteroid Secretion to Hypotension and Hypovolemia *JCI Insight, 1965
- Mechanism of volume replacement and vascular constriction following hemorrhageAmerican Journal of Physiology-Legacy Content, 1965
- Hormonal effects on lymphatic transport of interstitial albumin in the dogAmerican Journal of Physiology-Legacy Content, 1964
- Studies of Thoracic Duct Lymph and Blood Plasma in Oligemic HypotensionJAMA, 1964
- A Concept of Negative Interstitial Pressure Based on Pressures in Implanted Perforated CapsulesCirculation Research, 1963
- Quantitative Evaluation of the Circulatory Adjustment of Splenectomized Dogs to HemorrhageAmerican Journal of Physiology-Legacy Content, 1958
- Exchange of Water Between Blood and TissuesAmerican Journal of Physiology-Legacy Content, 1952
- DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTIONJournal of Biological Chemistry, 1949
- THE RELATIONSHIP OF THE ADRENAL GLANDS TO CHANGES IN URINARY NON-PROTEIN NITROGEN FOLLOWING MULTIPLE FRACTURES IN THE FORCE-FED RATAmerican Journal of Physiology-Legacy Content, 1947
- INTRACELLULAR FLUID LOSS IN HEMORRHAGEJCI Insight, 1936