Kinetic studies of the metabolism of foreign organic compounds. 3. The conjugation of phenols with glucuronic acid

Abstract

The rate of conjugation of phenol, catechol, resorcinol, quinol, m- and p-methoxy-, p-chloro- and p-cyano-phenols, and 2,6- and 3,4- xylen-1-ols with glucuronic acid in the rabbit was proportional to the body level of the phenol. For phenols, with small substituent radicals, except 2,6-xylen-l-ol, the velocity constants, kg, for glucuronide formation did not differ significantly from that for phenol itself. Phenols with substituent radical wt. greater than that of p-chlorophenol had significantly lower kg values. For the para-substituted phenols examined kg did not appear to be related to the electronic influence of the substituent group.