Kinetic studies of the metabolism of foreign organic compounds. 4. The conjugation of phenols with sulphuric acid
- 1 November 1952
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 52 (3), 419-423
- https://doi.org/10.1042/bj0520419
Abstract
In the fasting rabbit the rate of ethereal sulfate formation is independent of the amt. of phenol present above a certain body level, but the simultaneous admn. of a compound, such as Na2SO3 or L-cystine, which is converted to sulfate in vivo, changes the kinetics of the process to those of a lst-order reaction. The effect of various substituents on the value of the velocity constant for sulfate conjugation was determined. It did not appear to be related to the size or electronic influence of the substituent group.Keywords
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