Thymosin alpha 11: a peptide related to thymosin alpha 1 isolated from calf thymosin fraction 5.
- 1 December 1983
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 80 (24), 7424-7427
- https://doi.org/10.1073/pnas.80.24.7424
Abstract
Two peptides related to thymosin .alpha.1 were isolated from preparations of calf thymosin fraction 5. One, lacking 4 amino acid residues at the COOH terminus, is designated des-(25-28)-thymosin .alpha.1. The other, named thymosin .alpha.11, contains 7 additional amino acid residues at the COOH terminus. The sequence of this peptide is: AcSer-Asp-Ala-Ala-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Gly-Arg-Glu-Ala-Pro-Ala-AsnOH. Thymosin .alpha.11, in doses of < 300 ng/mouse, protects susceptible inbred murine strains against opportunistic infections with Candida albicans. It is .apprx. 30 times as potent as thymosin fractions 5 and approximately equal in potency to thymosin .alpha.1.This publication has 20 references indexed in Scilit:
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