Combination between different proteins and between proteins and yeast nucleic acid

Abstract

When ribonuclease, globin, clupein, serum albumin and serum globulin were mixed with each other, yeast nucleic acid or tobacco mosaic virus at pH values at which they were oppositely charged, they precipitated each other. Most of the precipitates could be dissolved by adding NaCl. Suspensions of heat-coagulated proteins behaved similarly to protein soln. The inhibiting effects of ribonuclease, globin and clupein on the infectivity of tobacco mosaic virus at pH 6.0 was diminished by 0.3 [image] NaCl. Changing pH from 6 to 9 reduced the inhibiting effects and combination with the virus of ribonuclease and globin, but not of clupein.