Mechanisms of Synthesis of Purine Nucleotides in Heart Muscle Extracts1
Open Access
- 1 November 1957
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 36 (11), 1572-1578
- https://doi.org/10.1172/jci103555
Abstract
Mechanisms of synthesis and degradation of purine nucleotides in an extract of pig heart muscle were studied. The more active synthetic pathways were via the phosphorylation of adenosine and the condensation of adenine or hypoxanthine with 5-phosphoribosyl-l-pyrophosphate (PRPP). De novo synthesis appeared less active. Evidence for the dephosphorylation of adenylic acid, as well as for the enzymes adenylic acid deaminase, adenosine deaminase, and nucleoside phosphorylase is presented.Keywords
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