PATERNAL AGE AND DOWN SYNDROME
- 1 January 1979
- journal article
- research article
- Vol. 31 (4), 489-497
Abstract
The frequency of Down syndrome (DS) in infants of older fathers was examined in 2 sets of data. The effect of maternal age was controlled by single years of age. Lack of tight control has been an important weakness of other studies on this subject. Data obtained in metropolitan Atlanta [Georgia, USA] by an intensive case-ascertainment program showed no overall excess of DS infants born to older fathers. No evidence of such an effect was seen in recent birth certificate data made available by the National Center for Health Statistics. The Atlanta data suggest an increased number of DS infants born to older fathers who had children by women .ltoreq. 34 yr. However, there was a small deficiency of DS infants born to older fathers by women .gtoreq. 35 yr. The possibility of a paternal-age effect remains open, but the available data suggest that, if it exists, it is quite small.This publication has 10 references indexed in Scilit:
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