Retardation of Tumor Growth in Mice by Oral Administration of Methyl Androstenediol and Methyl Testosterone

Abstract

The growth of sarcoma 180 or adenocarcinoma C3H-BA was markedly retarded in mice by oral admn. of methyl androstenediol or methyl testosterone in doses of approx. 100 mg./kg. daily, when treatment is started the day following implantation. Inhibition of sarcoma 37 and adenocarcinoma EO-771, under similar conditions, was slight and brief. No retardation of growth of sarcoma 180 was noted when 100 mg./kg. doses of the compounds were administered daily by subcut. injn.