The Oxygen-enhancement Ratio for Reproductive Death Induced by3H or125I Damage in Mammalian Cells
- 1 January 1975
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
- Vol. 28 (5), 417-425
- https://doi.org/10.1080/09553007514551241
Abstract
The oxygen-enhancement ratio (o.e.r.) for 3H- and 125I-induced cell death at 4°C was determined in cultured Chinese hamster cells. The o.e.r. for cell death induced by 3H-thymidine was 3·2, essentially the same value as that previously reported for X-ray induced cell death. For cell death induced by 125I-iododeoxyuridine (125IdUrd), the o.e.r. was less than 1·4. The lower o.e.r. for 125I-induced death was not due to the presence of the base analogue itself, since cells that had incorporated unlabelled IdUrd and were X-irradiated had an o.e.r. of 2·8 and cells that were inactivated by 3H-IdUrd damage at 4°C had an o.e.r. even greater than 3. These results suggest that 125I-decay damage, like high-linear-energy-transfer radiation damage, is only slightly increased by the presence of oxygen.Keywords
This publication has 9 references indexed in Scilit:
- Non-Repairable Strand Breaks Induced by 125 I Incorporated into Mammalian DNAProceedings of the National Academy of Sciences, 1974
- Repair replication induced by 3H incorporated into HeLa DNAMutation Research, 1974
- Variation in Radiation Response of Mammalian Cells as a Function of Oxygen TensionRadiation Research, 1973
- Biological Damage from Intranuclear Tritium: DNA Strand Breaks and Their RepairScience, 1972
- Measurements of very low oxygen tensions in unstirred liquidsAnalytical Chemistry, 1972
- Iodine-125, a tracer in cell biology: physical properties and biological aspectsPhysics in Medicine & Biology, 1970
- Destruction of Molecules by Nuclear TransformationsScience, 1967
- Formation of Fragment Ions from CH3Te125 and C2H5Te125 Following the Nuclear Decays of CH3I125 and C2H5I125The Journal of Chemical Physics, 1963