Effect of Lysergic Acid Diethylamide and Bufotenine on Performance of Trained Rats

Abstract

A study comparing the effect of lysergic acid diethylamide (LSD) and bufotenine on the climbing time of trained rats has been carried out. LSD was found to be effective at a lower dosage but had a shorter duration of action than bufotenine. It was shown that animals developed a tolerance as well as a cross tolerance to repeated injections of LSD or bufotenine. Submaximal doses of LSD and bufotenine were potentiated when brain serotonin levels were altered by pretreat-ment of the animals with reserpine, 5-hydroxytryptophan or iproniazid. However, highly effective doses of both psychogens were inhibited by 5-hydroxytryptophan pretreatment. Evidence presented in this study indicated that LSD and bufotenine prolong the climbing time of trained rats by a similar mechanism of action.