Effects of hypo- and hyper-capnia on myocardial blood flow and metabolism during epinephrine infusion in the dog
- 1 January 1986
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 64 (1), 44-49
- https://doi.org/10.1139/y86-006
Abstract
We hae previously demonstrated a 40% increase in myocardial blood flow (MBF) during hypercapnia but no significant decrease of MBF during hypocapnia. The present study was undertaken to evaluate if epinephrine infusion, which increases both myocardial oxygen consumption (.ovrhdot.VO2) and myocardial performance, might influence the effects of hypocapnia and hypercapnia on MBF. Induction of hypocapnia was performed by hyperventilation in closed-chest dogs anesthetized with pentobarbital. By adding carbon dioxide to the inspiratory gas, normocapnia and hypercapnia were created. Epinephrine infusion (0.8 .mu.g .cntdot. kg-1 .cntdot. min-1) increased MBF and cardiac output (CO) by 90 and 140%, respectively, while M.ovrhdot.VO2 was increased by 45%. Epinephrine had a direct coronary vasodilating effect in excess of myocardial needs evidenced by increased oxygen content of the coronary sinus blood. During epinephrine infusion, induction of hypocapnia effected no change of MBF, while myocardial oxygen extraction increased significantly. Although oxygen saturation (SO2) and PO2 in the coronary sinus blood decreased, these values remained well above those observed with hypocapnia without epinephrine infusion, thereby excluding impaired oxygen supply to the heart. Hypercapnia induced an increase of MBF by nearly 40% despite the coronary vasodilatation already induced by epinephrine infusion.This publication has 13 references indexed in Scilit:
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