A Study of Anuria Occurring During Apnea Under Diffusion Respiration

Abstract

This study concerns the role played by anhydremia and the renal nerves in the production of the anuria accompanying diffusion respiration. The technic employed for diffusion respiration was the same as that reported previously from this laboratory. A 45-min. period of apnea was used. Four series of 5 dogs each were carried out. Urine was collected by means of ureteral catheters. In series 1 (control), the renal innerv. was intact, and no intraven. fluid was given; in series 2, the renal innerv. was intact, and Plazmoid soln. was given intraven; in series 3 the renal innerv. was blocked by tetracaine on left side, and no intraven. fluid was given; in series 4, the renal innerv. was blocked by tetracaine on left side, and Plazmoid soln. was given intraven. In the presence of intact renal innervation anuria occurred consistently immediately after, or within a few minutes, of respiratory arrest. The admn. of Plazmoid soln. intraven. neither prevented nor delayed the onset of anuria in kidneys having intact renal innerv. Resumption of spontaneous respiration was followed immediately, or within a few min. by the return of urine secretion. Blocking the innerv. of the left kidney greatly delayed or, in the case of animals receiving Plazmoid intraven., usually prevented the appearance of anuria on the denervated side. In the latter instance, however, the volume of urine secreted was always greatly diminished. The possible mechanisms involved are discussed.