A CORRELATION OF THE pH OF ARTERIAL BLOOD AND URINE AS AFFECTED BY CHANGES IN PULMONARY VENTILATION

Abstract

Continuous blood and urine pH tracings under conditions produced by changes in pulmonary ventilation were recorded in the anesthetized dog by means of glass electrodes whose reliability had been carefully detd. CO2 and mechanical asphyxia caused a blood and urine pH decrease while low O2 and over-ventilation produced an increase in blood and urine pH. Urinary ammonia increased with decreased urinary pH and diminished with increased urinary pH. An inverse relationship between urinary chloride and phosphate was indicated in these studies. In general a chloride increase accompanied a pH increase in urine. The fact that urine pH changes in the same direction as that of the blood and within such a short time after the blood changes, together with the findings that the urinary constituents studied change in a direction such as to counteract the pH change of the blood, seems to indicate that the hydrogen ion is the factor primarily concerned in these studies.